With Rafael Nadal out with injury, can Novak Djokovic go past the Spaniard and pick up a record 23rd Grand Slam title.
Djokovic, playing his first tournament for six months because of an elbow problem, dropped his opening two service games and although he battled back to break Monfils twice he wavered again as scrappy opener went his opponents' way.
World number one Novak Djokovic lost to rivals Roger Federer and Andy Murray in the finals of US Open warm-up events but the Serb insists those defeats have aided his preparations for the last grand slam of the season.
Tsitsipas was philosophical in defeat.
Novak Djokovic will arrive at Roland Garros seven wins away from becoming the first man for 43 years to hold all four grand Slam titles concurrently -- the only trouble is one of his victims will probably have to be claycourt king Rafa Nadal.
'When it's easy it's going to be no problem. When it gets tough that's when you know what's going to hold up and what's not'
World number one Novak Djokovic was sensationally disqualified in the US Open fourth round on Sunday after striking a line judge with a ball following a point during the first set of his match against Spain's Pablo Carreno Busta.
Andre Agassi says that he and Novak Djokovic need to learn to trust each other if their partnership is to deliver results for the world number four.
The world number one was virtually guaranteed a semi-final berth before walking on court at the O2 Arena, but made doubly sure by cruising past Tomas Berdych in little more than an hour.
Novak Djokovic said it was good for men's tennis that the duopoly in Grand Slams had been broken on Thursday after he thumped Swiss Roger Federer to reach the Australian Open final.
Novak Djokovic won the Rome Masters for the fourth time by outwitting old rival Roger Federer on Sunday.
The Serb easily beat the Spaniard 6-3, 6-4 at the O2 Arena.
Murray, who has struggled with a persistent hip injury since the Briton's quarter-final exit at Wimbledon in July, pulled out of the US Open and dropped to 16th in the world rankings.
Andy Murray has what it takes to ruin Novak Djokovic's dreams of sweeping to a 'golden slam', coach Ivan Lendl has said as the Scot prepares for another tilt at the Wimbledon title.
Top seed and reigning champion Novak Djokovic pulled off the great escape at Wimbledon in beating South African Kevin Anderson 6-7(6), 6-7(6), 6-1, 6-4, 7-5 to reach his 25th successive grand slam quarter-final.
World number two Novak Djokovic hammered Swiss Stanislas Wawrinka 6-1, 6-4 to reach the Paris Masters semi-finals on Friday.
Roger Federer strolled to a 6-2, 7-5, 6-3 win over Novak Djokovic to reach the Australian Open quarter-finals.
Novak Djokovic may be using the Hopman Cup as preparation for this month's Australian Open but the world number three is also clearly enjoying himself at the mixed team event.
Novak Djokovic summoned some cinematic inspiration to help him conquer grand slam king Roger Federer and silence the roaring supporters of the Swiss at Sunday's US Open men's final.
World number one Novak Djokovic saw off Canadian Denis Shapovalov 6-3, 6-4 to win his fifth Paris Masters title on Sunday in a warning to his rivals ahead of the ATP Finals, while Ashleigh Barty finished the season in style by beating defending champion Elina Svitolina 6-4, 6-3 to add the WTA Finals title to her end-of-year world number one rank.ing
Novak Djokovic opened defence of his US Open title with a laboured 6-3, 5-7, 6-2, 6-1 win over Poland's Jerzy Janowicz on Monday that brought new concerns about the world number one's fitness.
For a set not even the granite defence of Novak Djokovic could withstand the irresistible brute force of Juan Martin del Potro on Sunday but the Serb then rode out the storm to win the opening semi-final at the ATP World Tour Finals.
World No 1 Novak Djokovic beat defending champion Andy Murray 6-2, 3-6, 6-3 in the Madrid Open final on Sunday to capture a record 29th Masters crown.
The Serbian had to save two set points in the first set before finding his groove to reach his 10th title clash in Rome and remain on course to win his 36th ATP Masters 1000 crown and overtake Rafael Nadal on the all-time list.
Top seed Novak Djokovic and Juan Martin Del Potro set a record for the longest semi-final ever played at Wimbledon on Friday as the Serb favourite eventually triumphed in the fifth set after four hours 43 minutes of scintillating action.
Images from the opening day of the Wimbledon tennis championships in London, on Monday.
Australia's Nick Kyrgios has branded Rafael Nadal a sore loser, the Spaniard's uncle Toni an "idiot" and said world number one Novak Djokovic has a "sick obsession" with being liked.
China's Li Na became the first player to reach the round of 16 at this year's US Open when she defeated Britain's Laura Robson 6-2, 7-5 on Friday.
World No. 1 Novak Djokovic raised his eyes and arms to the sky after beating Ukraine's Alexandr Dolgopolov to reach the Monte Carlo Masters quarter-finals on Thursday just hours after learning of the death of his grandfather.
Having exchanged a few shots with a young prospect after an intense training session in searing heat at his own tennis complex in central Belgrade, the 30-year old Serb conceded that the last 18 months have been testing.
Roger Federer and Novak Djokovic will be out to complete unfinished business at Wimbledon on Thursday after both were denied a chance to savour match-point glory in their first-round matches.
Novak Djokovic outclassed Finland's Jarkko Nieminen 6-4, 6-2, 6-3 to move safely into the Wimbledon third round on Wednesday.
Novak Djokovic's hopes of a calendar year Grand Slam are hanging by a thread as he slipped two sets down to big-serving American Sam Querrey before rain stopped their Wimbledon third- round clash in London, on Friday.
Novak Djokovic crushed Andy Murray 6-1, 7-5, 7-6(3) on Sunday to match Roy Emerson's record of six Australian Open titles and leave the Briton heartbroken again at Melbourne Park.
Djokovic may never feel the affections of the crowd savoured by Federer and Spaniard Rafael Nadal but his record of 16 Grand Slam titles is proof that tennis is no popularity contest.
A relieved Novak Djokovic said he hoped his bad match was out of the way after he battled past little-known American qualifier Jesse Witten in the third round of the U.S. Open on Saturday. The fourth-seeded Serb was pushed hard by the world number 276, who had considered quitting the sport at the start of this year, before finally scraping through 6-7, 6-3, 7-6, 6-4.
Former French Open champion Carlos Moya said Novak Djokovic has the potential to become world number one.
World number one Novak Djokovic extended his winning run in Asia when he strolled into the last-16 of the Shanghai Masters.
World No 2 Djokovic, who received a first-round bye, broke his opponent's serve four times to extend his winning run to 19 matches.
Novak Djokovic boosted his chances of finishing the season as world number one when he became the first player to retain his Paris Masters title with a 6-2, 6-3 win over big-serving Canadian Milos Raonic in the final on Sunday.